Ahead of their high-profile clash on Saturday, check out the five standout clashes between Arsenal and Chelsea.
The hosts struggled to break down Arsene Wenger's side despite enjoying the majority of possession and will feel hard done by after crafting the best of the game's few openings in a lively game at Stamford Bridge.
Diego Costa scored twice but could not prevent Chelsea losing their 100 percent Premier League record in a controversial 2-2 draw at Swansea on Sunday.
Chelsea have topped the spending list with Manchester United not far behind, but West Ham United's business epitomises the TV riches which give all Premier League clubs spending power that only the elite teams in Spain or Germany can dream of.
Images from the English Premier League matches played on Saturday
Giampiero Ventura, a 68-year-old who has never won a major title, was named on Tuesday as the next Italy coach to replace Antonio Conte after Euro 2016.
Italy midfielder Alessandro Florenzi believes they can prove the doubters wrong again in Friday's Euro 2016 clash with Sweden in Toulouse.
On a day of frenetic spending that took the Premier League total to a record far above one billion pounds ($1.29 billion), Antonio Conte's side also missed out on two of their other targets - Alex Oxlade-Chamberlain and Fernando Llorente.
Arsenal travel across town to a vengeful Chelsea on Saturday knowing that another depressing defeat at Stamford Bridge would see their Premier League title hopes swept away with the lunchtime leftovers.
Chelsea midfielder Cesc Fabregas gave his manager a reminder of his talents by scoring twice in extra time as they fought back from two goals down to knock Premier League champions LeicesterCity out of the League Cup 4-2 on Tuesday.
Images from the English Premier League London derby played between Arsenal and Chelsea at the Emirates on Wednesday
A stunning strike from Jordan Henderson helped Liverpool secure a comfortable 2-1 win at Chelsea on Friday that ended the London club's unbeaten start to the season and underlined the growing potential of Juergen Klopp's side.
Rediff.com brings a preview of the main matches coming up this weekend in the English Premier League.
The visitors got off to the perfect start when a mix up at the back saw Riyad Mahrez square for Jamie Vardy to tap into an open goal in front of the Kop in the third minute. Liverpool looked for an immediate riposte, but Salah missed two gilt-edged opportunities before Sadio Mane saw an effort disallowed for offside as Juergen Klopp's men grew frustrated.
News of all that's transpired on and off the football field
Real Madrid's Welsh winger Gareth Bale has joined Lionel Messi and Cristiano Ronaldo in the race for FIFA's Ballon d'Or award.
Liverpool were sent spinning to a 2-0 defeat at promoted Burnley in the English Premier League on Saturday while Chelsea came from behind to win 2-1 at Watford thanks to late goals from Michy Batshuayi and Diego Costa.
The challenge against champions Chlesea on Sunday is for Manchester United to show that they can replicate the confident and businesslike win that City showed a month ago.
LeicesterCity manager Claudio Ranieri hopes Chelsea midfielder N'Golo Kante will be given a warm reception when he returns to his old stomping ground for the first time since leaving the English champions.
Irresistible Chelsea go into the Christmas round of fixtures knowing they can end the year by re-writing the record books.
Former Chelsea midfielder Frank Lampard has hailed John Terry as the Premier League's greatest ever defender after the club announced their captain will leave Stamford Bridge at the end of the season.
Spending by Premier League teams has already broken last season's record and could exceed one billion pounds ($1.32 billion) by the time the transfer window closes at the end of the month.
Tottenham Hotspur have appointed former Celtic coach Ange Postecoglou as their new manager on a four-year contract.
Images from the English Premier League matches played on Sunday.
IMAGES from the EPL matches played on Saturday
Chelsea a 1-0 win over Manchester United in a compelling Premier League clash on Sunday
Following is a match by match look at the English Premier League's weekend fixtures:
Jose Mourinho will have no qualms about frustrating entertainment-hungry Manchester United fans if it means securing a win on his return to Stamford Bridge on Sunday.
Champions Chelsea have not enjoyed the best of starts at home this season and face their biggest test yet on Saturday with the visit of free-scoring leaders Manchester City.
Former player and reserve team boss Santiago Solari has been put in caretaker charge after negotiations between the club and former Chelsea, Italy and Juventus boss Antonio Conte broke down on Monday, the club added.
Chelsea manager Antonio Conte was fuming at the final whistle after Pedro and Alvaro Morata were dismissed in extra time and two penalty appeals had been waved away, but the Premier League champions regained their composure to win the shootout 5-3.
Premier League champions Chelsea eased past a disappointing Everton with goals from Spaniards Cesc Fabregas and Alvaro Morata sealing a 2-0 victory on Sunday.
Chelsea maintained their stranglehold on the Premier League by beating Sunderland 1-0 on Wednesday to register their 10th successive win and move six points clear at the top of the table.
Chelsea made light of striker Diego Costa's absence to extend their lead at the top of the Premier League to seven points with a 3-0 win at champions Leicester City.
Chelsea midfielder Cesc Fabregas has quashed persistent transfer rumours, saying he had never thought of leaving the StamfordBridge and that he is extremely happy with his current club.
Chelsea captain John Terry is assessing whether to retire from football after the Premier League champions' final game of the season against Sunderland on Sunday.
Chelsea kept alive their remote Premier League title chances with a 2-0 win over London rivals Tottenham Hotspur on Sunday, set on their way by an exquisite strike from Hakim Ziyech which was quickly followed up by a Thiago Silva header.
News of all that's transpired on and off the football field
Manchester City manager Pep Guardiola has been named the Premier League manager of the month for February, while in-form Tottenham Hotspur striker Harry Kane picked up his fourth player of the month award.
A stoppage-time goal from Martin de Roon earned Middlesbrough an unlikely 1-1 draw at Premier League leaders Manchester City on Saturday.
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